Estrogen receptor alpha gene variants and major depressive episodes

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Estrogen receptor alpha gene variants and major depressive episodes.

BACKGROUND Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants and lifetime major depression has been insufficiently studied. METHODS 3987 community-dwelling women aged 65years and over were recruited in France as part of the Three City Study. Current and past major depressive disorders (MDD) were diagnosed using the Mini-Interna...

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Major depressive episodes and random mood.

CONTEXT Mathematical models describing changes in mood in affective disorders may assist in the identification of underlying pathologic and neurobiologic mechanisms and in differentiating between alternative interpretations of psychiatric data. OBJECTIVE Using time-to-event data from a large epidemiologic survey on recovery from major depression, to model the survival probability, in terms of...

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Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia

Estrogen modifies human emotion and cognition and impacts symptoms of schizophrenia. We hypothesized that the variation in the estrogen receptor alpha (ESR1) gene and cortical ESR1 mRNA is associated with schizophrenia. In a small case-control genetic association analysis of postmortem brain tissue, genotype CC (rs2234693) and haplotypes containing the C allele of a single-nucleotide polymorphi...

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Polymorphisms in the estrogen receptor alpha gene and mammographic density.

The presence of the PvuII or the XbaI polymorphism in the estrogen receptor alpha gene (ESR1, 6q25) has been related to breast cancer risk; however, results are not fully consistent. To further elucidate this relation, we examined these polymorphisms in relation with mammographic density, a measure of dense tissue in the breast, which is strongly associated with breast cancer risk. For this stu...

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ژورنال

عنوان ژورنال: Journal of Affective Disorders

سال: 2012

ISSN: 0165-0327

DOI: 10.1016/j.jad.2011.10.010